Zack was born in Jerusalem, Israel. He received his B.Sc. in Chemistry at the Hebrew University of Jerusalem in 2009. Then he obtained his M.Sc. and Ph.D. in Organic Chemistry as part of the direct track to Ph.D. program under the supervision of Professor Jochanan Blum in 2014. His mission was to develop new homogenous and heterogenous reaction conditions to enable better control over the regioselectivity of catalytic organic reactions.

Upon the completion of his Ph.D, Zack joined the group of Professor Ilan Marek at Technion-Israel Institute of Technology as a postdoctoral researcher where he worked on stereoselective transformations of metalated systems. In 2017, he joined the group of Professor Frank Glorius at the Organisch-Chemisches Institute, WWU-Münster, Germany as a Minerva and VATAT postdoctoral fellow. During that time, Zack focused on the chemoselective hydrogenation of fluoroarenes.

In 2020, Zack joined the Institute of Chemistry at the Hebrew University of Jerusalem as a Senior Lecturer (Assistant Professor). He was awarded with MAOF Fellowship for outstanding young investigators, and the Neubauer Foundation Fellowship for excellent young Principal Investigators.