Catalytic Transfer Hydrogenation of Arenes and Heteroarenes

Citation:

Coralie Gelis, Arne Heusler, Zackaria Nairoukh, and Frank Glorius. 2020. “Catalytic Transfer Hydrogenation of Arenes and Heteroarenes.” Chem. Eur. J. 2020, 26, 14090 – 14094. Publisher's Version

Abstract:

Abstract Transfer hydrogenation reactions are of great interest to reduce diverse molecules under mild reaction conditions. To date, this type of reaction has only been successfully applied to alkenes, alkynes and polarized unsaturated compounds such as ketones, imines, pyridines, etc. The reduction of benzene derivatives by transfer hydrogenation has never been described, which is likely due to the high energy barrier required to dearomatize these compounds. In this context, we have developed a catalytic transfer hydrogenation reaction for the reduction of benzene derivatives and heteroarenes to form complex 3-dimensional scaffolds bearing various functional groups at room temperature without needing compressed hydrogen gas.

Notes:

https://doi.org/10.1002/chem.202002777
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Last updated on 05/19/2021