Publications

2018
Mario P. Wiesenfeldt, Zackaria Nairoukh, and Frank Glorius. 2018. “Verfahren zur Herstellung fluorierter cyclischer aliphatischer Verbindungen.” Germany WO/2018/177661. Publisher's Version
Jian Qiang Huang, Zackaria Nairoukh, and Ilan Marek. 2018. “Electrophilic Fluorination of Stereodefined Disubstituted Silyl Ketene Hemiaminals en route to Tertiary α-Fluorinated Carbonyl Derivatives.” Org. Biomol. Chem. 2018, 16, 1079 – 1082. Publisher's Version Abstract
A highly diastereoselective synthesis of tertiary α-fluoro carbonyl compounds is reported in only two chemical steps from a simple alkyne through the reaction of stereodefined fully substituted silyl ketene hemiaminal derivatives with Selectfluor.
Jian Qiang Huang, Zackaria Nairoukh, and Ilan Marek. 2018. “Electrophilic Oxidation of Stereodefined Polysubstituted Silyl Ketone Aminals.” Eur. J. Org. Chem. 2018, 614 – 618. Publisher's Version Abstract
We reported herein a practical approach to acyclic tertiary α-hydroxy carbonyl compounds in only two chemical steps from alkynes with excellent diastereoselectivity through the oxidation of stereodefined polysubstituted silyl ketone aminals. The products could be smoothly converted to synthetically useful enantiomerically enriched 1,2-diol derivatives.