Electrophilic Fluorination of Stereodefined Disubstituted Silyl Ketene Hemiaminals en route to Tertiary α-Fluorinated Carbonyl Derivatives

Citation:

Jian Qiang Huang, Zackaria Nairoukh, and Ilan Marek. 2018. “Electrophilic Fluorination of Stereodefined Disubstituted Silyl Ketene Hemiaminals en route to Tertiary α-Fluorinated Carbonyl Derivatives.” Org. Biomol. Chem. 2018, 16, 1079 – 1082. Publisher's Version

Abstract:

A highly diastereoselective synthesis of tertiary α-fluoro carbonyl compounds is reported in only two chemical steps from a simple alkyne through the reaction of stereodefined fully substituted silyl ketene hemiaminal derivatives with Selectfluor.
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Last updated on 05/19/2021