Electrophilic Fluorination of Stereodefined Disubstituted Silyl Ketene Hemiaminals en route to Tertiary α-Fluorinated Carbonyl Derivatives

Citation:

Huang, J. Q. ; Nairoukh, Z. ; Marek, I. . Electrophilic Fluorination Of Stereodefined Disubstituted Silyl Ketene Hemiaminals En Route To Tertiary Α-Fluorinated Carbonyl Derivatives. Org. Biomol. Chem. 2018, 16, 1079 – 1082 2018.

Date Published:

2018

Abstract:

A highly diastereoselective synthesis of tertiary α-fluoro carbonyl compounds is reported in only two chemical steps from a simple alkyne through the reaction of stereodefined fully substituted silyl ketene hemiaminal derivatives with Selectfluor.

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Last updated on 05/19/2021