Electrophilic Oxidation of Stereodefined Polysubstituted Silyl Ketone Aminals

Citation:

Jian Qiang Huang, Zackaria Nairoukh, and Ilan Marek. 2018. “Electrophilic Oxidation of Stereodefined Polysubstituted Silyl Ketone Aminals.” Eur. J. Org. Chem. 2018, 614 – 618. Publisher's Version

Abstract:

We reported herein a practical approach to acyclic tertiary α-hydroxy carbonyl compounds in only two chemical steps from alkynes with excellent diastereoselectivity through the oxidation of stereodefined polysubstituted silyl ketone aminals. The products could be smoothly converted to synthetically useful enantiomerically enriched 1,2-diol derivatives.

Notes:

https://doi.org/10.1002/ejoc.201701516
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Last updated on 05/19/2021