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Stereodefined Acyclic Polysubstituted Silyl Ketene Aminals: Asymmetric Formation of Aldol Products with Quaternary Carbon Stereocenters | The Nairoukh Research Group

Stereodefined Acyclic Polysubstituted Silyl Ketene Aminals: Asymmetric Formation of Aldol Products with Quaternary Carbon Stereocenters

Citation:

Nairoukh, Z. ; Marek, I. . Stereodefined Acyclic Polysubstituted Silyl Ketene Aminals: Asymmetric Formation Of Aldol Products With Quaternary Carbon Stereocenters. Angew. Chem. Int. Ed. 2015, 54, 14393 – 14397 2015.

Date Published:

2015

Abstract:

Abstract The regio- and stereoselective formation of stereodefined polysubstituted silyl ketene aminals is easily achieved through selective combined carbometalation?oxidation?silylation reactions. These substrates are ideal candidates for Mukaiyama aldol reactions with aliphatic aldehydes as they give the aldol products with a quaternary carbon stereocenter α to the carbonyl groups in outstanding diastereoselectivities.

Notes:

https://doi.org/10.1002/anie.201507209

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Last updated on 05/19/2021